Research & Drug Development

Salvati P.; Maj R.; Caccia C.; Cervini M.A.; Lamberti E.; Pevarello P.; Skeen G.A.; White H.S.; Wolf H.H.; Faravelli L.; Mazzanti M.; Mancinelli E.; Varasi M.; Fariello R.G.
Biochemical and Electrophysiological Studies on the Mechanism of Action of PNU-151774E, a Novel Antiepileptic Compound.
J.Pharmac.Exp. Ther.; 288: 1151-1159, 1999

Maj R.; Fariello R.G.; Pevarello P.; Varasi M.; McArthur R.A.; Salvati P.
Anticonvulsant Activity of PNU-151774E in the Amygdala Kindled Model of Complex Partial Seizures.
Epilepsia, 40: 1523-1528, 1999

Pevarello P.; Traquandi G.; Bonsignori A.; McArthur R.A.; Maj R.; Caccia C.; Salvati P.; Varasi M.
Synthesis and Preliminary Biological Evaluation of New a-Amino Amide Anticonvulsants Incorporating a Dextromethorphan Moiety.
Biorg. Med.Lett., 9:1783-1788, 1999

Pevarello P.; Bonsignori A.; Caccia C.; Amici R.; McArthur R.A.; Fariello R.G.; Salvati P.; Varasi M.
Sodium Channel Activity and Sigma Binding of Enantiomeric 2-Aminopropanamide Anticonvulsants.
Biorg. Med. Lett.; 9:2512-2524, 1999

Salvati P.; Maj R.; McArthur R.A.; Cervini M.A.; Kozak W.; Benatti L.; Fariello R.G.
PNU-151774E, a Novel Na+Channel Blocker, Shows Analgesic Effects in Some Animal Models.
Soc. for Neuroscience, Abs 25(2): 1947, 1999

Maj R.; Calabresi M.; Caccia C.; Salvati P.; Fariello R.G.
PNU-151774E, A Combined MAO-B and Glutamate Release Inhibitor, is Effective in Animal Models of Parkinson's Disease
Soc. for Neuroscience, Abs, 25(2): 1599, 1999