Newron in a nutshell

Newron is a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain.

We are committed to delivering innovative treatments to improve the quality of life for patients with CNS disorders. Our team has built a balanced and robust pipeline comprised of drug candidates at different clinical stages and has a proven track record of drug development and commercialization.

Xadago® (safinamide) has received marketing authorization for the treatment of Parkinson’s disease in the European Union and Switzerland (both 2015) as well as in the U.S. (2017) and is commercialized in Europe by Newron’s Partner Zambon. Supernus Pharmaceuticals holds the commercialization rights in the US. Valeo Pharma holds the commercialization rights for the Canadian market, Seqirus for Australia & New Zealand, and Medison for Israel. Meiji Seika, in collaboration with Eisai, has the rights to develop and commercialize the compound in Japan and other key Asian territories.

In addition to Xadago® for Parkinson’s disease, Newron has a strong pipeline of promising treatments including Evenamide as the potential first add-on therapy for the vast majority of schizophrenic patients who are poor responders or treatment resistant to their current anti-psychotic therapy, including clozapine.

Founded in 1999, Newron is headquartered in Bresso, near Milan, Italy, with a subsidiary in Morristown, NJ, USA. The Company is listed on the SIX Swiss Exchange, under the trading symbol NWRN, on the primary market of the Düsseldorf Stock Exchange and on XETRA, trading symbol NP5.

 
Board of Directors Board of Directors

Strategy

Maximize Xadago’s market potential

Xadago® is the first New Chemical Entity in a decade approved in Europe and the U.S.  for the treatment of Parkinson’s disease (PD). The product is commercialized in a number of European markets as well as in the USA. Our partners Zambon and Meiji Seika Pharma are working towards global approval.

Newron receives milestone and royalty payments from sales of Xadago® in PD.

Leverage CNS expertise — New concept in treating inadequate/non-response in schizophrenia

Newron is developing Evenamide as add-on therapy for the vast majority of schizophrenic patients who are poor responders or treatment resistant to their current anti-psychotic therapy, including clozapine.

Newron plans to partner opportunities directed at larger markets when offered the best return to Newron’s shareholders.

Partner non-core assets and in-license strategically relevant assets

Partnering is an important part of our strategy. We are actively engaging potential partners about our innovative pipeline of novel compounds to enable our products to be brought to market by companies with the best expertise. In addition, we are continuously searching for strategically relevant assets to in-license and expand our clinical portfolio.

Our People

Ulrich Köstlin
Read more Chairman, Non-executive director, Chairman of compensation and nomination committee
Patrick Langlois
Read more Non-executive director, Chairman of audit & risk committee, member of compensation and nomination committee
Luca Benatti
Read more Non-executive director, member of R&D and audit & risk committees
Ulrich Köstlin
Chairman, Non-executive director, Chairman of compensation and nomination committee

Chairman of the Board since 2013. He was member of the Board of Management of Bayer Schering Pharma AG until 2011 and was responsible for multiple regions globally – Europe, Asia Pacific, Latin America, Japan and North America. He began his pharmaceutical career with Schering AG as a management trainee in 1982. Over the years, he served as General Manager for several subsidiaries of Schering AG across the globe, including from 1990 to 1993 as Vice President Sales and Marketing and General Manager Diagnostic Imaging of the U.S. subsidiary. In 1994, Ulrich was appointed to the former Schering AG’s Executive Board. He currently serves as Curator of the AREPO Foundation, Liechtenstein and is Deputy Chairman on the Boards of Constantia Flexibles AG, Vienna and Director on the Board of Universitätklinikum Würzburg, Germany. Ulrich studied law at the Universities of Erlangen and Tübingen in Germany, and the University of Geneva in Switzerland. He holds a Dr. iur. Doctorate from Tübingen University and a Master of Laws (LL.M.) degree from the University of Pennsylvania Law School. Ulrich is the Chairman of Newron’s Compensation and Nomination Committee. He is German.

 

Patrick Langlois
Non-executive director, Chairman of audit & risk committee, member of compensation and nomination committee

Patrick Langlois, a director since 2008, was the CFO and Vice-Chairman of the Management Board of Aventis from 2002 to 2005 and served for 30 years in various senior financial functions at Rhône-Poulenc and the Aventis Group in France and the USA. Prior to that, he was with Banque Louis-Dreyfus. He currently is General Partner of PJL Conseils, a consulting firm in healthcare. He holds a doctorate in economics from the University of Rennes (France). Patrick Langlois is Director on the Board of Directors and Chairman of the Audit Committee of Innate Pharma S.A. (France) and Chairman of Sensorion S.A. (France). He is French. Patrick is the Chairman of Newron’s audit and risk committee and member of the compensation and nomination committee.

Luca Benatti
Non-executive director, member of R&D and audit & risk committees

Luca Benatti is Chief Executive Officer and member of the Board of TES Pharma. He has over 30 years’ experience in Pharma and Biotech. He was the CEO of EryDel since 2012, recently acquired by Quince Therapeutics. and the Co-founder and CEO of Newron Pharmaceuticals. Under his guidance, Newron developed a pipeline of innovative therapies including Xadago, approved worldwide for the treatment of Parkinson's disease. He is an independent Board member at Newron Pharmaceuticals (NWRN), Quince (QNCX), Cas Revolution, Chairman of the Italian Angels for Biotech, Member of the Advisory Board of the Sofinnova-Telethon fund. He has authored several scientific publications and holds numerous patents. Luca is Italian citizen. Luca is a member of the R&D and the audit and risk committees. Luca is Italian citizen

Gillian Dines
Read more Non-executive director, Chairwoman of R&D committee, member of BD committee
Margarita Chavez
Read more Non-executive director, Chairwoman of BD committee, member of R&D and audit & risk committees
Stefan Weber
Read more Executive director, CEO
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Gillian Dines
Non-executive director, Chairwoman of R&D committee, member of BD committee

Gillian is the Chief Scientific Officer at Juvenescence UK LTD since October 2023 and has 30+ years of experience in research, development, approval, and commercialization of new medicines in both “Big Pharma” and as an entrepreneur in the biotech environment. She holds a Master of Science in Toxicology from the University of Surrey and a Bachelor of Science from University of Leeds in Biochemistry and Genetics. Before her current role in Juvenescence, she was Senior Vice President and Head of Research and Early Development at Jazz Pharmaceuticals, SVP R&D Operations at GW Pharmaceuticals and also VP Head of New Medicines Strategic Planning at UCB. One of her key roles in 2008 was Company Director and Chief Development Officer at RespiVert, a UK based biotech that delivered clinical phase assets from start-up to acquisition by global pharma player in only 18 months, within £20M budget. Her previous experience covers various leadership roles at GlaxoSmithKline. In her career she led 20+ novel medicines and devices through successful IND and clinical submissions in areas of respiratory, immunology, rare disease, anti-infective and neurology therapy areas. Gillian is member of the BD committee. She is English

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Margarita Chavez
Non-executive director, Chairwoman of BD committee, member of R&D and audit & risk committees

Margarita Chavez brings to Newron over 20 years of dealmaking expertise and leadership in the pharmaceutical industry. Most recently, she was Managing Director of AbbVie Ventures, where she led investments and built biotech companies across the US and Europe.  Margarita also served as a board member for several biotech companies across the US and Europe. As a Director in Abbott’s Global Pharmaceutical Licensing & Acquisitions Division, she was involved in the successful in-licensing of Elagolix and the acquisitions of Solvay, ImmuVen and the Lupron franchise. Before joining Abbott, Margarita practiced as a corporate and securities lawyer in the Silicon Valley, advising tech and biotech companies on strategic transactions including IPOs and mergers and acquisitions. She received her bachelor’s degree from Santa Clara University and her juris doctor from Santa Clara University School of Law (both California). She is currently a Venture Partner at Wellington Partners and has been acting as advisor to Newron’s board since October 1, 2023. Margarita is the Chairwoman of Newron’s BD committee, member of the R&D and audit and risk committees. She is American.

Stefan Weber
Executive director, CEO

Stefan Weber was appointed Chief Executive Officer and Executive Director of Newron in 2012. He had been Chief Financial Officer of the Company since April 2005. Stefan holds a master’s degree in business management from FernUniversität Hagen (Diplom-Kaufmann). He has more than 30 years of industry experience in finance and general management. From 2001 to 2005, he was the Chief Financial Officer of Biofrontera, a company active in drug discovery and development. He joined Girindus, a fine chemistry process development and scale-up provider, in 1999, and was appointed Chief Financial Officer in 2000. From 1987 to 1999, he was with Lohmann Group, a worldwide producer of pharmaceutical, medical, technical and consumer products. His final position was Head of Finance of the Group. Stefan has executed numerous major financing transactions, debt, equity and mezzanine as well as national and European grants. He has also executed successful IPOs to the Frankfurt and Zurich stock exchanges and has been involved in a number of M&A transactions, divestments and strategic restructurings. He is German.

Our History

  • Up to today

    • exceptional one-year results of study 014/15 with evenamide in TRS
    • positive top-line results from potentially pivotal Phase II/III study 008A with evenamide in schizophrenia patients

  • Evenamide

    • striking six-month results from its exploratory clinical trial evaluating evenamide as add-on therapy for patients with treatment-resistant schizophrenia

  • Evenamide

    • encouraging interim results for evenamide in patients with Treatment-Resistant Schizophrenia (TRS)

  • Evenamide Phase II/III

    • initiation of Study 008A, the 1st potentially pivotal study with evenamide in patients with schizophrenia 
    • initiation of pilot Study 014: evenamide as add-on treatment in patient wih moderated to severeTRS
    • initial results from two short-…

  • Working to progress the development of evenamide

    • Safinamide has now been successfully launched in 18 countries
    • Shares listed also on the primary market of the Düsseldorf Stock Exchange and on XETRA

  • Xadago® (safinamide) approved by US FDA

    received EUR 11.3m milestone payments from Zambon

  • Xadago® (safinamide) approved in EU

  • progress in development and new alliance

    • Completion of the Phase III for Safinamide
    • License agreements with Meji Seika Pharma and Zambon for Safinamide
    • US FDA IND approval for NW-3509 (2011)

  • IPO on the SWX Swiss Exchange

    €74.3m raised - one of the top 3 global biotech IPOs of this year

  • from 2000 to 2005

    • 3 rounds of VC funding: 3i, Atlas, Apax, HBM, TVM for a total of €63m
    • US IND approval for safinamide in Parkinson's disease

ESG

We are committed to delivering innovative treatments to improve the quality of life for patients with CNS disorders. We do so by maximizing the market potential of our product Xadago, developing our compound Evenamide as add-on therapy for the treatment of positive symptoms of schizophrenia, and by partnering non-core assets and in-licensing strategically relevant assets.

While doing so, Newron's Board of Directors and Senior Management Team are committed to high standards of corporate governance, including transparency and accountability towards the company’s stakeholders. The corresponding Corporate Governance reporting is updated on a yearly basis and available in the most recent Annual Report here.

Newron has identified the following stakeholder groups to be of specific relevance for the company’s future success:

  • Employees: Newron strives to offer an inspiring work environment. The well-being of our employees is key. Commitment is rewarded. It is the company’s ambition to act as motivating and attractive employer of choice within the global CNS community. Newron does not tolerate any form of harassment and treats all employees equally.
  • Patients: It is our main purpose to improve the life of patients with CNS disorders. We do so by developing proprietary compounds as well as partnering and in-licensing assets. When conducting clinical trials, we carefully select the KOL and CRO that are responsible for planning and running the studies jointly with us and the involved authorities. We have the utmost respect for patients willing to participate in our clinical trials and avoid all issues (e.g. discrimination of specific populations) that might occur.
  • R&D and Business partners: For Newron, sustainable collaborations with R&D and business partners is very important. Newron aims to act as reliable business partner, following and respecting the industry’s business ethics – and requires the same from its partners.
  • Investors and financial community: Newron’s ambition is to create value for its shareholders in the long-term. Thus, Newron maintains a constant and trustful dialogue with shareholders, the financial community as well as the Swiss (SIX) and German (XETRA) stock exchanges where Newron’s shares are currently traded. Transparent communications is crucial. Risk management and business continuity play an important role in Newron’s corporate strategy.
  • Society: Newron aims to be a Good Corporate Citizen, i.e. in the Milan (Italy) and New Jersey (USA) areas where the company currently has its offices. The same applies to locations where Newron is present within the framework of clinical trials. We pay attention to our ecological footprint and are working on further improving it.