Newron in a nutshell

Newron (SIX: NWRN, XETRA: NP5) is a publicly listed biopharmaceutical company committed to improving the lives of patients with central and peripheral nervous system disorders.

Our lead compound, evenamide, is a first-in-class glutamate modulator currently in Phase III development. Evenamide has the potential to become the first add-on therapy for patients with treatment-resistant schizophrenia (TRS) and for poorly responding patients with chronic schizophrenia. Clinical data to date demonstrates significant and sustained improvements in key efficacy measures alongside a favourable safety profile – a rare combination amongst the currently available antipsychotic medications.

We have entered into development and commercialization agreements for evenamide with EA Pharma (a subsidiary of Eisai) for Japan and other Asian territories, as well as with Myung In Pharm for South Korea. Additional partnerships for other territories are currently being evaluated.

Newron has a proven track record in bringing CNS therapies to market. Our Parkinson’s disease treatment, Xadago® (safinamide), is approved in over 20 markets, including the USA, UK, EU, Switzerland, and Japan, and commercialized in partnerships with Zambon and Meiji Seika.

Board of Directors Board of Directors

Strategy

Advancing evenamide – transforming schizophrenia treatment

Evenamide is our lead development asset and represents a potential breakthrough in the treatment of schizophrenia. Its differentiated mechanism of action (MoA) targets a significant unmet medical need in a large global market.

  • Unique MoA: glutamate modulation through voltage-gated sodium channel blockade
  • Add-on approach to enhance efficacy of existing antipsychotics
  • Positive Phase II/III data and ongoing Phase III trials

Leveraging partnerships – enabling global reach

We aim to expand our network of strategic partners to support evenamide’s global development and commercialization. Recent collaborations in Asia provide a strong foundation for further development opportunities in other territories.

Expanding our pipeline through strategic in-licensing

In parallel, we are evaluating opportunities to in-license innovative CNS assets to strengthen and diversify our development portfolio.

Our People

Stefan Weber
Read more Executive director, CEO
Ravi Anand
Read more CMO
Roberto Galli
Read more CFO
Stefan Weber
Executive director, CEO

Stefan Weber was appointed Chief Executive Officer and Executive Director of Newron in 2012. He had been Chief Financial Officer of the Company since April 2005. Stefan holds a master’s degree in business management from FernUniversität Hagen (Diplom-Kaufmann). He has more than 30 years of industry experience in finance and general management. From 2001 to 2005, he was the Chief Financial Officer of Biofrontera, a company active in drug discovery and development. He joined Girindus, a fine chemistry process development and scale-up provider, in 1999, and was appointed Chief Financial Officer in 2000. From 1987 to 1999, he was with Lohmann Group, a worldwide producer of pharmaceutical, medical, technical and consumer products. His final position was Head of Finance of the Group. Stefan has executed numerous major financing transactions, debt, equity and mezzanine as well as national and European grants. He has also executed successful IPOs to the Frankfurt and Zurich stock exchanges and has been involved in a number of M&A transactions, divestments and strategic restructurings. He is German.

Ravi Anand
CMO

Ravi Anand, a Swiss resident, has been the Company’s Chief Medical Officer since 2005. He received his university education in New Delhi, India, and his medical training, specialising in psychiatry and neurology, in the U.S. For over 20 years, Ravi has worked in international drug development and regulatory affairs at major pharmaceutical companies, including F. Hoffmann-La Roche (Switzerland), Sandoz/Novartis (US) and Organon (Netherlands). From 1993 to 1997, Ravi was the Medical Director of CNS, Clinical Research at Sandoz Research Institute. From 1997 to 2001, he served as the international Head of CNS Medical Affairs at Novartis and, from 2001 to 2003, as the global Head of CNS Clinical Research at Organon. Since 2003, Ravi has been acting as a consultant for Newron and other clients. During his tenure in the pharmaceutical industry, he worked in all phases (I through III) of drug development as well as in post-marketing studies (Phase IV). In total, he has been responsible for the conduct of clinical trials in over 30 countries and been involved in over 30 investigational new drug applications, and over 7 international new drug applications. He has published over 50 papers and 200 abstracts, posters and presentations. He is both a U.S. and a Swiss citizen.

Roberto Galli
CFO

Roberto Galli was appointed Chief Financial Officer of Newron effective July 1st, 2023. He has been Vice President Finance of the Company since 2012. He has more than 20 years of experience in industry finance and auditing. He joined Newron in 2002. He has held several management positions within the Finance Department and has been involved in the Company’s IPO, as well as M&A and other strategic corporate transactions: he was instrumental in finalizing the EIB funding facility. Before joining Newron, he was Senior Auditor & Business Advisor at PricewaterhouseCoopers (PwC), leading auditing projects in companies from the pharmaceutical, fashion, energy and automotive industries. He started his career as an auditor at Coopers&Lybrand. He holds a master degree in business economics from the University Luigi Bocconi in Milan and is registered with the national register of auditors. He is also a member of the Italian Angels for Biotech Association. Roberto Galli is Italian.

Dennis Dionne
Read more VP Commercial Affairs
Filippo Moriggia
Read more VP Operations
Laura Faravelli
Read more VP Business Development
Dennis Dionne
VP Commercial Affairs

Dennis Dionne has been Vice President of Commercial Affairs since January 2017. He joined Newron Pharmaceuticals as Executive Director of Commercial Operations in 2015. Dennis has tremendous experience in the CNS arena and served in a variety of commercial leadership roles at Johnson & Johnson (21 years), at Novartis (6 years) has pioneered a number of small venture start-ups. He has proven abilities in planning and management at both strategic and operational levels, including building full life-cycle commercial strategies at the pre-launch stage and managing the business through various stages of growth. Dennis holds a BA in Biology & Chemistry from Roger Williams University, Bristol, RI and has successfully completed executive leadership programs in general management and operational leadership, commercial policies and practices, marketing and project management and global cross functional team leadership. Dennis Dionne is a U.S. citizen. 

Filippo Moriggia
VP Operations

Filippo Moriggia was appointed Vice President Operations of Newron effective July 1st, 2022. He has held several management positions, including IT, HR and compliance responsibilities, since he joined Newron in 2016. He has more than 15 years of experience as an IT professional advisor. He started his career as a technical editor for different national magazines of the Mondadori Group. He holds a master degree in Engineering from the Politecnico di Milano and is a licensed professional engineer since 2005. Filippo Moriggia is Italian. 

Laura Faravelli
VP Business Development

Laura Faravelli was appointed VP Business Development on July 1, 2023. Since 2015, Laura has held various management roles in Newron’s business development function.  She has over 20 years of experience in international research, development and regulatory approval of new products for central nervous system indications and in drug repositioning. Laura holds a PhD in Neurobiology and a master’s degree in Regulatory Affairs and Market Access.  Before transitioning to business development, she held management positions in Newron’s R&D unit, including in discovery, pharmacology research and non-clinical development, contributing to successful European Medicines Agency marketing authorisation application (MAA) and US Food and Drug Administration new drug application (NDA) processes. She started her post-academic career at Pharmacia & Upjohn. Laura Faravelli is Italian.

 

Our History

  • Up to today

    • license agreement signed with Myung In Pharm for evenamide in South Korea

  • license agreement signed with EA Pharma for evenamide

    • exceptional 1 year results of study 014/15 in TRS
    • positive top-line results from study 008A in schizophrenia

  • Evenamide

    • striking six-month results from its exploratory clinical trial evaluating evenamide as add-on therapy for patients with treatment-resistant schizophrenia

  • Evenamide

    • encouraging interim results for evenamide in patients with Treatment-Resistant Schizophrenia (TRS)

  • Evenamide Phase II/III

    • initiation of Study 008A, the 1st potentially pivotal study with evenamide in patients with schizophrenia 
    • initiation of pilot Study 014: evenamide as add-on treatment in patient wih moderated to severeTRS
    • initial results from two short-…

  • Working to progress the development of evenamide

    • Safinamide has now been successfully launched in 18 countries
    • Shares listed also on the primary market of the Düsseldorf Stock Exchange and on XETRA

  • Xadago® (safinamide) approved by US FDA

    received EUR 11.3m milestone payments from Zambon

  • Xadago® (safinamide) approved in EU

  • progress in development and new alliance

    • Completion of the Phase III for Safinamide
    • License agreements with Meji Seika Pharma and Zambon for Safinamide
    • US FDA IND approval for NW-3509 (2011)

  • IPO on the SWX Swiss Exchange

    €74.3m raised - one of the top 3 global biotech IPOs of this year